Excellgen/pRB(视网膜母细胞瘤蛋白)/RP-104/5000 U
市场价:
¥6760.00
美元价:
3042.00
产品分类:
其它动物抗原
公司分类:
Other_animal_antigens
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
ProductName | pRB(Retinoblastomaprotein) |
Size | 5000U |
Description | RB,theproductofretinoblastomasusceptibilitygeneRB-1,isoneofthebest-studiedtumorsuppressorgeneproducts.AtleasttwootherpRB-relatedproteins,p107andp138,havebeenidentifiedandcharacterized.MutationsinZB-1geneareoftenassociatedwiththeoccurrenceofvarioustumors(1-3).TheactivityofpRBisregulatedthroughphosphorylationinacellcycle-dependentmanner.ThehyperphosphorylatedRBproteinusuallyassociateswiththecellnucleusandbindstranscriptionfactorsoftheE2Ffamily(4,5).pRBrepressestranscriptionofitstargetgenes,suchascdc2,cyclinA,andoncogenec-Myc,c-FosthroughthebindingwithE2Ffactorsandtherebyregulatingcellproliferation(6). |
Applications |
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Source | Baculovirus-insectcell |
FusionTag | 6XHis |
PurificationMethod | FPLC |
UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein.1unitissufficientforagelmobilityshiftassayina20µlreaction;50unitsaresufficientforreconstitutedtranscriptionassayand100unitsaresufficientforaprotein-proteininteractionassay |
Purity | ~95%asdeterminedbySDS-PAGE |
GeneID | 5925 |
Accession# | NM_000321 |
GeneName | retinoblastoma1 |
GeneSymbol | RB-1 |
GeneSynonyms | RB;pRb;OSRC;pp110;p105-Rb |
MW | 107.5kDa |
ProteinSequence | TPRKTAATAAAAAAEPPAPPPPPPPEEDPEQDSGPEDLPLVRLEFEETEEPDFTALCQKL KIPDHVRERAWLTWEKVSSVDGVLGGYIQKKKELWGICIFIAAVDLDEMSFTFTELQKNI EISVHKFFNLLKEIDTSTKVDNAMSRLLKKYDVLFALFSKLERTCELIYLTQPSSSISTE INSALVLKVSWITFLLAKGEVLQMEDDLVISFQLMLCVLDYFIKLSPPMLLKEPYKTAVI PINGSPRTPRRGQNRSARIAKQLENDTRIIEVLCKEHECNIDEVKNVYFKNFIPFMNSLG LVTSNGLPEVENLSKRYEEIYLKNKDLDARLFLDHDKTLQTDSIDSFETQRTPRKSNLDE EVNVIPPHTPVRTVMNTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGY IFKEKFAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLNDNIFHM SLLACALEVVMATYSRSTSQNLDSGTDLSFPWILNVLNLKAFDFYKVIESFIKAEGNLTR EMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDREGPTDHLESACPLNLPLQNNHTAAD MYLSPVRSPKKKGSTTRVNSTANAETQATSAFQTQKPLKSTSLSLFYKKVYRLAYLRLNT LCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRHLDQIMMCSMYGICKVKNIDLKFKII VTAYKDLPHAVQETFKRVLIKEEEYDSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPH IPRSPYKFPSSPLRIPGGNIYISPLKSPYKISEGLPTPTKMTPRSRILVSIGESFGTSEK FQKINQMVCNSDRVLKRSAEGSNPPKPLKKLRFDIEGSDEADGSKHLPGESKFQQKLAEM TSTRTRMQKQKMNDSMDTSNKEEK |
StorageBuffer | 20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA |
Storage | -20to-80°C. |
Shipping | 4°Cordryice |
References | 1.Friend,SH.etal.,(1986)Nature323,643-646 2.Lee,WH.etal.,(1987)Science235,1394-1399 3.OnADIm,Z.etal.,(1992)Proc.Natl.Acad.Sci.USA89,6177-6181 4.Chen,PL.etal.,(1989)Cell58,1193-1198 5.Ludlow,JW.etal.,(1989)Cell56,57-65 6.Hinds,PW.etal.,(1992)Cell70,993-1006 |
品牌介绍
ExcelGene是一家私人拥有和科学驱动的公司,由Florian M.Wurm教授于2001年创建,自2017年起由首席执行官Maria João Wurm博士领导。我们的总部设在瑞士的蒙蒂。F、 Wurm是旧金山南部基因科技公司(Genentech Inc.)的前经理和科学家,也是为第一批在CHO细胞中制造药物蛋白质而开发制造工艺的先驱科学家之一。Maria J.De Jesus,现在的Maria J.Wurm,ExcellGene的共同创始科学家,在位于洛桑的瑞士联邦理工学院(EPFL)担任高级科学家,发明并开发了多项突破性技术。这些发明对细胞系的发展产生了深远的影响,有些已经在临床生物制剂的早期研发工作中得到了全球应用。ExcelGene面向全球客户,致力于挑战蛋白质表达目标。