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当前位置: 首页 > 产品中心 > Other_animal_antigens > Excellgen/BRCA1(肿瘤抑制蛋白和转录因子)/RP-110/2000 U
商品详细Excellgen/BRCA1(肿瘤抑制蛋白和转录因子)/RP-110/2000 U
Excellgen/BRCA1(肿瘤抑制蛋白和转录因子)/RP-110/2000 U
Excellgen/BRCA1(肿瘤抑制蛋白和转录因子)/RP-110/2000 U
商品编号: RP-110
品牌: Excellgen
市场价: ¥6800.00
美元价: 3060.00
产地: 美国(厂家直采)
公司:
产品分类: 其它动物抗原
公司分类: Other_animal_antigens
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
ProductNameBRCA1(TumorSuppressorProteinandTranscriptionFactor)
Size2,000U
DescriptionThehumanBRCA1,theproductofbreastandovariancancergene1,isahyperphosphorylatedproteinfunctioningasatumorsuppressorinvolvedinbothtranscriptionregulationandDNArepair.BRCA1associateswithRAD51andhasshowntoberequiredfortranscription-coupledrepairofDNAdamageaswellasfortherepairofchromosomaldouble-strandbreaks(1-5).AssociationwithahumanSWI/SNF-relatedcomplexhasrecentlysuggestedapotentialroleofBRCA1inlinkingchromatinremodelingtobreastcancer(6).
Applications
  • invitrofunctionstudiesincludingtranscriptionandDNArepair
  • protein-proteininteractionassay
  • cellgrowthassay
SourceBaculovirus-insectcell
FusionTag6XHis
PurificationMethodFPLC
UnitDefinition(Activity)1unit=1nanogramofpurifiedprotein.1unitissufficientforagelmobilityshiftassayina20µlreaction;50unitsaresufficientforreconstitutedtranscriptionassayand100unitsaresufficientforaprotein-proteininteractionassay
Purity

~95%asdeterminedbySDS-PAGE

GeneID672
Accession#NM_007294
GeneNameBRCA1breastcancer1,earlyonset
GeneSymbolBRCA1
GeneSynonymsIRIS;PSCP;BRCAI;BRCC1;PNCA4;RNF53;BROVCA1;PPP1R53
MW209.1kDa
ProteinSequence1MDLSALRVEEVQNVINAMQKILECPICLELIKEPVSTKCDHIFCKFCMLKLLNQKKGPSQ
61CPLCKNDITKRSLQESTRFSQLVEELLKIICAFQLDTGLEYANSYNFAKKENNSPEHLKD
121EVSIIQSMGYRNRAKRLLQSEPENPSLQETSLSVQLSNLGTVRTLRTKQRIQPQKTSVYI
181ELGSDSSEDTVNKATYCSVGDQELLQITPQGTRDEISLDSAKKAACEFSETDVTNTEHHQ
241PSNNDLNTTEKRAAERHPEKYQGSSVSNLHVEPCGTNTHASSLQHENSSLLLTKDRMNVE
301KAEFCNKSKQPGLARSQHNRWAGSKETCNDRRTPSTEKKVDLNADPLCERKEWNKQKLPC
361SENPRDTEDVPWITLNSSIQKVNEWFSRSDELLGSDDSHDGESESNAKVADVLDVLNEVD
421EYSGSSEKIDLLASDPHEALICKSERVHSKSVESNIEDKIFGKTYRKKASLPNLSHVTEN
481LIIGAFVTEPQIIQERPLTNKLKRKRRPTSGLHPEDFIKKADLAVQKTPEMINQGTNQTE
541QNGQVMNITNSGHENKTKGDSIQNEKNPNPIESLEKESAFKTKAEPISSSISNMELELNI
601HNSKAPKKNRLRRKSSTRHIHALELVVSRNLSPPNCTELQIDSCSSSEEIKKKKYNQMPV
661RHSRNLQLMEGKEPATGAKKSNKPNEQTSKRHDSDTFPELKLTNAPGSFTKCSNTSELKE
721FVNPSLPREEKEEKLETVKVSNNAEDPKDLMLSGERVLQTERSVESSSISLVPGTDYGTQ
781ESISLLEVSTLGKAKTEPNKCVSQCAAFENPKGLIHGCSKDNRNDTEGFKYPLGHEVNHS
841RETSIEMEESELDAQYLQNTFKVSKRQSFAPFSNPGNAEEECATFSAHSGSLKKQSPKVT
901FECEQKEENQGKNESNIKPVQTVNITAGFPVVGQKDKPVDNAKCSIKGGSRFCLSSQFRG
961NETGLITPNKHGLLQNPYRIPPLFPIKSFVKTKCKKNLLEENFEEHSMSPEREMGNENIP
1021STVSTISRNNIRENVFKEASSSNINEVGSSTNEVGSSINEIGSSDENIQAELGRNRGPKL
1081NAMLRLGVLQPEVYKQSLPGSNCKHPEIKKQEYEEVVQTVNTDFSPYLISDNLEQPMGSS
1141HASQVCSETPDDLLDDGEIKEDTSFAENDIKESSAVFSKSVQKGELSRSPSPFTHTHLAQ
1201GYRRGAKKLESSEENLSSEDEELPCFQHLLFGKVNNIPSQSTRHSTVATECLSKNTEENL
1261LSLKNSLNDCSNQVILAKASQEHHLSEETKCSASLFSSQCSELEDLTANTNTQDPFLIGS
1321SKQMRHQSESQGVGLSDKELVSDDEERGTGLEENNQEEQSMDSNLGEAASGCESETSVSE
1381DCSGLSSQSDILTTQQRDTMQHNLIKLQQEMAELEAVLEQHGSQPSNSYPSIISDSSALE
1441DLRNPEQSTSEKAVLTSQKSSEYPISQNPEGLSADKFEVSADSSTSKNKEPGVERSSPSK
1501CPSLDDRWYMHSCSGSLQNRNYPSQEELIKVVDVEEQQLEESGPHDLTETSYLPRQDLEG
1561TPYLESGISLFSDDPESDPSEDRAPESARVGNIPSSTSALKVPQLKVAESAQSPAAAHTT
1621DTAGYNAMEESVSREKPELTASTERVNKRMSMVVSGLTPEEFMLVYKFARKHHITLTNLI
1681TEETTHVVMKTDAEFVCERTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDV
1741VNGRNHQGPKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSFTL
1801GTGVHPIVVVQPDAWTEDNGFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQIPH
1861SHY
StorageBuffer

20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA

Storage-20to-80°C.
Shipping4°Cordryice
References1.Maldonado,E.etal.,(1996)Nature381,86-89
2.Scully,R.etal.,(1997)Proc.Natl.Acad.Sci.USA94,5605-5610
3.Sharan,SK.etal.,(1997)Nature386,804-810
4.Wang,Y.etal.,(2000)Genes&Dev.14,927-939
5.Cantor,SB.etal.,(2001)Cell105,149-160
6.Bochar,DA.etal.,(2000)Cell102,257-265
品牌介绍
ExcelGene是一家私人拥有和科学驱动的公司,由Florian M.Wurm教授于2001年创建,自2017年起由首席执行官Maria João Wurm博士领导。我们的总部设在瑞士的蒙蒂。F、 Wurm是旧金山南部基因科技公司(Genentech Inc.)的前经理和科学家,也是为第一批在CHO细胞中制造药物蛋白质而开发制造工艺的先驱科学家之一。Maria J.De Jesus,现在的Maria J.Wurm,ExcellGene的共同创始科学家,在位于洛桑的瑞士联邦理工学院(EPFL)担任高级科学家,发明并开发了多项突破性技术。这些发明对细胞系的发展产生了深远的影响,有些已经在临床生物制剂的早期研发工作中得到了全球应用。ExcelGene面向全球客户,致力于挑战蛋白质表达目标。