Excellgen/FGF-1(酸性成纤维细胞生长因子)/RP-114/5000 U
市场价:
¥5200.00
美元价:
2340.00
产品分类:
其它动物抗原
公司分类:
Other_animal_antigens
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
ProductName | FGF-1(acidicfibroblastgrowthfactor) |
Size | 5,000U |
Description | Acidicfibroblastgrowthfactor(FGF-1)andbasicfibroblastgrowthfactor(FGF-2)areubiquitouscytokinesfoundinmanytissues.Theyhaveeffectsonmultiplecelltypesderivedfrommesodermandneuroectoderm,includingendothelialcells(1).FGFproteinsaresmallpeptidesof155to268aminoacidresidues(2-4).Thedegreeofsequenceidentitybetweendifferentfamilymembersis30-60%ina"centraldomain"of~120aminoacids.ThisdomainconferstoFGFsacommontertiarystructureandtheABIlitytobindtoheparin(5).SecretedFGFssignaltotargetcellsbybindingandactivatingcell-surfacetyrosinekinaseFGFreceptors(FGFRs;6,7).ThefunctionofFGFsandFGFRsduringembryonicdevelopmentandadultphysiologyhasbeenaddressedbygain-andloss-of-functionexperimentsinseveralanimalmodelorganisms.ThesestudieshaveshownthatFGFsactaskeyregulatorsofdevelopmentalevents(8,9). |
Source | Baculovirus-insectcell |
FusionTag | 6XHis |
PurificationMethod | FPLC |
UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein.20unitsaresufficientforaDNA-proteinassayand100unitsaresufficientforaprotein-proteininteractionassay |
Purity | ~95%asdeterminedbySDS-PAGE |
GeneID | 2246 |
Accession# | NM_000800 |
GeneName | fibroblastgrowthfactor1(acidic) |
GeneSymbol | FGF1 |
GeneSynonyms | AFGF;ECGF;FGFA;ECGFA;ECGFB;FGF-1;HBGF1;HBGF-1;GLIO703;ECGF-beta;FGF-alpha |
MW | 19.2kDa |
ProteinSequence | MAEGEITTFTALTEKFNLPPGNYKKPKLLYCSNGGHFLRILPDGTVDGTRDRSDQHIQLQ LSAESVGEVYIKSTETGQYLAMDTDGLLYGSQTPNEECLFLERLEENHYNTYISKKHAEK NWFVGLKKNGSCKRGPRTHYGQKAILFLPLPVSSD |
StorageBuffer | 20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA |
Storage | -20to-80°C. |
Shipping | 4°Cordryice |
References | 1.SlavinJ.,(1995)CellBiolInt.5,431-44. 2.Cuevas,P.,etal.,(1995)NeurolRes17,396-399 3.DeMoerlooze,L.,etal.,(2000)Development127,483-492 4.Hebert,JM,etal.,(1990)DevBiol138,454-463 5.Faham,S.,etal.,(1996)Science271,1116-1120 6.Dionne,CA,etal.,(1990)EMBOJ9,2685-2692 7.Johnson,DE,andWilliamsLT(1993)AdvCancerRes60,1-41 8.Arman,E,etal.,(1998)ProcNatlAcadSciUSA95,5082-5087 9.Gage,FH.(2000)Science287,1433-1438 |
品牌介绍
ExcelGene是一家私人拥有和科学驱动的公司,由Florian M.Wurm教授于2001年创建,自2017年起由首席执行官Maria João Wurm博士领导。我们的总部设在瑞士的蒙蒂。F、 Wurm是旧金山南部基因科技公司(Genentech Inc.)的前经理和科学家,也是为第一批在CHO细胞中制造药物蛋白质而开发制造工艺的先驱科学家之一。Maria J.De Jesus,现在的Maria J.Wurm,ExcellGene的共同创始科学家,在位于洛桑的瑞士联邦理工学院(EPFL)担任高级科学家,发明并开发了多项突破性技术。这些发明对细胞系的发展产生了深远的影响,有些已经在临床生物制剂的早期研发工作中得到了全球应用。ExcelGene面向全球客户,致力于挑战蛋白质表达目标。