Excellgen/SV40 T抗原(猿猴病毒40大抗原)/RP-116/5000 U
市场价:
¥5200.00
美元价:
2340.00
产品分类:
其它动物抗原
公司分类:
Other_animal_antigens
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
ProductName | SV40T-Antigen(SimianVirus40LargeAntigen) |
Size | 5,000U |
Description | ThelargeTantigen(TAg)ofSimianvirus40actsasaninitiatorofDNAreplication,participatesincellulartransformation,andinducescellgrowth(1-4).AnumberoffunctionaldomainshavebeencharacterizedincludingtheN-terminalJdomain,nuclearlocalizationsignal(NLS),internalhelicasedomain,RbandtopoisomeraseIinteractingdomain,p53andATPbindingdomain(5,6).Thep53-interactingdomainisalsoessentialforbindingp300/CBP(7).PhosphorylationofTAgbyseveralkinasesmayregulateitsfunctionbothpositivelyandnegatively(8). |
Applications |
|
Source | Baculovirus-insectcell |
FusionTag | 6XHis |
PurificationMethod | FPLC |
UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein.50-500unitsaresufficientforaninvitrounwindingassayand100unitsaresufficientforaprotein-proteininteractionassay. |
Purity | ~95%asdeterminedbySDS-PAGE |
GeneID | 11039991 |
Accession# | AAG39214.1 |
GeneName | SV-12_gp5largeTantigen |
GeneSymbol | SV-12_gp5 |
MW | 83.3kDa |
ProteinSequence | MDKVLNREESLQLMDLLGLERSAWGNIPLMRKAYLKKCKEFHPDKGGDEEKMKKMNTLYK KMEDGVKYAHQPDFGGFWDATEIPTYGTDEWEQWWNAFNEENLFCSEEMPSSDDEATADS QHSTPPKKKRKVEDPKDFPSELLSFLSHAVFSNRTLACFAIYTTKEKAALLYKKIMEKYS VTFISRHNSYNHNILFFLTPHRHRVSAINNYAQKLCTFSFLICKGVNKEYLMYSALTRDP FSVIEESLPGGLKEHDFNPEEAEETKQVSWKLVTEYAMETKCDDVLLLLGMYLEFQYSFE MCLKCIKKEQPSHYKYHEKHYANAAIFADSKNQKTICQQAVDTVLAKKRVDSLQLTREQM LTNRFNDLLDRMDIMFGSTGSADIEEWMAGVAWLHCLLPKMDSVVYDFLKCMVYNIPKKR YWLFKGPIDSGKTTLAAALLELCGGKALNVNLPLDRLNFELGVAIDQFLVVFEDVKGTGG ESRDLPSGQGINNLDNLRDYLDGSVKVNLEKKHLNKRTQIFPPGIVTMNEYSVPKTLQAR FVKQIDFRPKDYLKHCLERSEFLLEKRIIQSGIALLLMLIWYRPVAEFAQSIQSRIVEWK ERLDKEFSLSVYQKMKFNVAMGIGVLDWLRNSDDDDEDSQENADKNEDGGEKNMEDSGHE TGIDSQSQGSFQAPQSSQSVHDHNQPYHICRGFTCFKKPPTPPPEPET |
StorageBuffer | 20mMTris-HClpH7.9,100mMNaCl,0.2mMEDTA,1mMDTTand20%glycerol |
Storage | -20to-80°C. |
Shipping | 4°Cordryice |
References | 1.FanningE.,(1992)J.Viol.66,1289-1293. 2.PanZQ.etal.,(1996)J.Biol.Chem.271,22111-22116. 3.Chao,HA.etal.,(2000)Mol.Cell.Biol.20,7624-7633. 4.Quartin,RS.etal.,(1994)J.Viol.68,1334-1341. 5.Marton,A.etal.,(1993)NucleicAcidsRes.21,1689-1695. 6.Kim,HY.etal.,(2001)EMBOJ.20,295-304. 7.Lill,NL.etal.,(1997)Nature387,823-827. 8.Moarefi,IF.etal.,(1993)J.Viol.67,4992-5002. |
品牌介绍
ExcelGene是一家私人拥有和科学驱动的公司,由Florian M.Wurm教授于2001年创建,自2017年起由首席执行官Maria João Wurm博士领导。我们的总部设在瑞士的蒙蒂。F、 Wurm是旧金山南部基因科技公司(Genentech Inc.)的前经理和科学家,也是为第一批在CHO细胞中制造药物蛋白质而开发制造工艺的先驱科学家之一。Maria J.De Jesus,现在的Maria J.Wurm,ExcellGene的共同创始科学家,在位于洛桑的瑞士联邦理工学院(EPFL)担任高级科学家,发明并开发了多项突破性技术。这些发明对细胞系的发展产生了深远的影响,有些已经在临床生物制剂的早期研发工作中得到了全球应用。ExcelGene面向全球客户,致力于挑战蛋白质表达目标。