Excellgen/核因子样2、NRF2、NFE2L2、核因子红系2相关因子2/RP-123/100
市场价：
¥5000.00
美元价：
2250.00
产品分类：
其它动物抗原
公司分类：
Other_animal_antigens
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductName | Nuclearfactor-like2,NRF2,NFE2L2 |
| Size | 100µg |
| Description | Nuclearfactor(erythroid-derived2)-like2,alsoknownasNFE2L2orNrf2,isatranscriptionfactorthatbindstotheantioxidantresponseelement(ARE)oftargetgenesinresponsetooxidativestressandincreasesthetranscriptionofavarietyofantioxidativeandcarcinogen-detoxificationenzymes.Stresscanresultfromavarietyofcauses,includingfasting,overfeeding,endogenouscompounds,exposuretochemicals,orenvironmentalagents,whichgenerallyleadstoincreasedproductionofreactiveoxygenspecies(ROS).Undernormalconditions,Nrf2isboundtoKelchlike-ECH-associatedprotein1(Keap1).Keap1actsasasubstrateadaptorproteinforCullin3-basedubiquitination,whichresultsinthedegradationofNrf2,andundernormalconditionsNrf2hasahalf-lifeofonly20minutes.OxidativestressorelectrophilicstressdisruptscriticalcysteineresiduesinKeap1,resultinginadisruptionoftheKeap1-Cul3ubiquitinationsystemandabuild-upofNrf2inthecytoplasmandtranslocatestothenucleus,whereitbindstoAREstoinduceexpressionofmultiplecytoprotectiveenzymes,includingNAD(P)H-quinoneoxidoreductase1(NQO1),glutathioneS-transferases(GSTs),andhemeoxygenase1(HO-1)(1,2). Nrf2alsoinducesseveraltranscriptionfactorsinvolvedinmitochondrialbiogenesis.ManylinesofevidencesuggestthatmitochondrialdysfunctionplaysacentralroleinthepathogenesisofPD.Thus,Nrf2maybeapromisingtargettocounteractmitochondrialdysfunctionanditsconsequencesinParkinson'sdisease(PD)(3).TheKeap1–Nrf2regulatorysystemisadouble-edgedswordforourbody.High-levelNrf2activityincreasescellprotectionandmakesthecellresistanttooxidativeandelectrophilicstresses.Therefore,Nrf2inducerscouldbeeffectiveforcancerchemoprevention.Ontheotherhand,elevatedNrf2activityisalsoadvantageousforcancercellsurvivalandevolution.Thus,Nrf2inhibitorscouldbeeffectiveforanticancertherapy.(4) |
| Applications | DNA-protein,protein-proteininteractionresearchandassaydevelopment. |
| Source | E.coli |
| FusionTag | 6XHis |
| PurificationMethod | FPLC |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 4780 |
| Accession# | NP_006155,NM_006164 |
| GeneName | Nuclearfactor(erythroid-derived2)-like2 |
| GeneSymbol | NFE2L2 |
| GeneSynonyms | NRF2 |
| MW | 69.9kDa |
| ProteinSequence | MMDLELPPPGLPSQQDMDLIDILWRQDIDLGVSREVFDFSQRRKEYELEKQKKLEKERQE QLQKEQEKAFFAQLQLDEETGEFLPIQPAQHIQSETSGSANYSQVAHIPKSDALYFDDCM QLLAQTFPFVDDNEVSSATFQSLVPDIPGHIESPVFIATNQAQSPETSVAQVAPVDLDGM QQDIEQVWEELLSIPELQCLNIENDKLVETTMVPSPEAKLTEVDNYHFYSSIPSMEKEVG NCSPHFLNAFEDSFSSILSTEDPNQLTVNSLNSDATVNTDFGDEFYSAFIAEPSISNSMP SPATLSHSLSELLNGPIDVSDLSLCKAFNQNHPESTAEFNDSDSGISLNTSPSVASPEHS VESSSYGDTLLGLSDSEVEELDSAPGSVKQNGPKTPVHSSGDMVQPLSPSQGQSTHVHDA QCENTPEKELPVSPGHRKTPFTKDKHSSRLEAHLTRDELRAKALHIPFPVEKIINLPVVD FNEMMSKEQFNEAQLALIRDIRRRGKNKVAAQNCRKRKLENIVELEQDLDHLKDEKEKLL KEKGENDKSLHLLKKQLSTLYLEVFSMLRDEDGKPYSPSEYSLQQTRDGNVFLVPKSKKP DVKKN |
| StorageBuffer | 20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.IshiiT.,ItohK.,YamamotoM(2002)RolesofNrf2inactivationofantioxidantenzymegenesviaantioxidantresponsiveelements.MethodsEnzymol348:182–190. |
品牌介绍
ExcelGene是一家私人拥有和科学驱动的公司，由Florian M.Wurm教授于2001年创建，自2017年起由首席执行官Maria João Wurm博士领导。我们的总部设在瑞士的蒙蒂。F、 Wurm是旧金山南部基因科技公司（Genentech Inc.）的前经理和科学家，也是为第一批在CHO细胞中制造药物蛋白质而开发制造工艺的先驱科学家之一。Maria J.De Jesus，现在的Maria J.Wurm，ExcellGene的共同创始科学家，在位于洛桑的瑞士联邦理工学院（EPFL）担任高级科学家，发明并开发了多项突破性技术。这些发明对细胞系的发展产生了深远的影响，有些已经在临床生物制剂的早期研发工作中得到了全球应用。ExcelGene面向全球客户，致力于挑战蛋白质表达目标。
