Excellgen/TNF-α(低内毒素)/RP-124/10µ;G
市场价:
¥4400.00
美元价:
1980.00
产品分类:
其它动物抗原
公司分类:
Other_animal_antigens
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
ProductName | TNF-alpha(LowEndotoxin) |
Size | 10µg |
Description | Tumornecrosisfactoralpha(TNFαorTNFSF2)isproducedbymanydifferentcelltypesincludingactivatedmonocytes,fibroblasts,endothelialcells,macrophages,T-cells,B-lymphocytes,granulocytes,smoothmusclecells,eosinophilis,chondrocytesandothercelltypes(1).Itfunctionsasacytokineinvolvedincellproliferation,differentiation,apoptosis,lipidmetabolismandcoagulation(2,3).HighlevelofTNFαleadstothedevelopmentofinflammatoryresponsesthatarehallmarksofmanydiseasesincludingautoimmunediseases,insulinresistanceandcancer(4,5).TheactiveformofTNFa(18kDa)isgeneratedbythecleavageofanAla-Valbondbetweenresidues76-77oftheprecursorprotein(6). |
Applications | cytotoxicityassaysandothercellassays |
Source | E.coli |
FusionTag | 6XHis |
PurificationMethod | FPLC |
UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein. |
Purity | ~95%asdeterminedbySDS-PAGE |
GeneID | 7124 |
Accession# | NM_000594 |
GeneName | tumornecrosisfactor |
GeneSymbol | TNF |
GeneSynonyms | DIF;TNFA;TNFSF2;TNF-alpha |
MW | 21kDa |
ProteinSequence | VRSSSRTPSDKPVAHVVANPQAEGQLQWLNRRANALLANGVELRDNQLVVPSEGLYLIYS QVLFKGQGCPSTHVLLTHTISRIAVSYQTKVNLLSAIKSPCQRETPEGAEAKPWYEPIYL GGVFQLEKGDRLSAEINRPDYLDFAESGQVYFGIIAL |
StorageBuffer | 20mMTris-HClpH7.9,100mMNaCl,0.2mMEDTA,1mMDTTand20%glycerol |
Storage | -20to-80°C. |
Shipping | 4°Cordryice |
References | 1.Locksley,R.etal.,(2001)Cell104,487-501 2.Mukhopadhyay,S.etal.,(2006)RespiratoryRes.7,1-9 3.Aggarwal,B.(2003)Nat.Rev.Immunol.3,745-756 4.Walczak,H.etal.,(1999)Nat.Med.5,157-163 5.Lam,J.etal.,(2000)J.Clin.Invest.106,1481-1488 6.Mcgeehan,G.etal.,(1994)Nature370,558-561 |
品牌介绍
ExcelGene是一家私人拥有和科学驱动的公司,由Florian M.Wurm教授于2001年创建,自2017年起由首席执行官Maria João Wurm博士领导。我们的总部设在瑞士的蒙蒂。F、 Wurm是旧金山南部基因科技公司(Genentech Inc.)的前经理和科学家,也是为第一批在CHO细胞中制造药物蛋白质而开发制造工艺的先驱科学家之一。Maria J.De Jesus,现在的Maria J.Wurm,ExcellGene的共同创始科学家,在位于洛桑的瑞士联邦理工学院(EPFL)担任高级科学家,发明并开发了多项突破性技术。这些发明对细胞系的发展产生了深远的影响,有些已经在临床生物制剂的早期研发工作中得到了全球应用。ExcelGene面向全球客户,致力于挑战蛋白质表达目标。