Excellgen/维甲酸X受体α，RXRA/RP-141/10000 U
市场价：
¥4400.00
美元价：
1980.00
产品分类：
转录表达
公司分类：
Target_Expression
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductName | RetinoidXReceptoralpha,RXRA |
| Size | 10,000U |
| Description | Nuclearreceptorsformthelargestknownfamilyoftranscriptionfactorsandhaveacrucialroleinnearlyallaspectsofvertebratedevelopmentandadultphysiologybytransducingtheeffectsofhormonesintotranscriptionalresponses(1).Thefamilyisdefinedbytwodomains:(a)thecentral,highlyconserved,DNA-bindingdomain(DBD)ofapprox.66aminoacids,and(b)theC-terminal,structurallyconserved,ligand-bindingdomain(LBD)ofapprox.250aminoacids(2,3).InadditiontobindingtoDNAandactivatingtranscriptioninresponseto9-cisretinoicacid,RXRformsheterodimerswiththereceptorsforthyroidhormone(TR),retinoicacid(RAR),vitaminD(VDR),prostanoids(PPAR),andnumerousorphanreceptors(4).RXRactsasbothactivatorandrepressoroftranscription(5).Intheabsenceofhormone,RXR(homo-orheterodimer)interactswithSMRT(silencingmediatorforretinoidandthyroidhormonereceptors)andN-CoR(nuclearreceptorcorepressor)andrepressestranscriptionthroughrecruitmentofhistonedeacetylases(6,7).Inthepresenceofhormone,RXRinteractswithanumberofactivatorsincludingtheSRC-1family(8),CBP/p300(9),pCAF(10)andtheTRAPcomplex(11)totargetchromatinacetylationactivateoftranscription(12) |
| Applications |
|
| Source | E.coli |
| FusionTag | 6XHis |
| PurificationMethod | FPLC |
| UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein.1unitissufficientforagelmobilityshiftassayina20µlreaction;100unitsaresufficientforprotein-proteininteractionassays |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 6256 |
| Accession# | NM_002957 |
| GeneName | retinoidXreceptor,alpha |
| GeneSymbol | RXRA |
| GeneSynonyms | NR2B1 |
| MW | 53.3kDa |
| ProteinSequence | MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPING MGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVP AHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLID KRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAEL AVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVIL LRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDM QMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLL RLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT |
| StorageBuffer | 20mMTris-HCl,pH8.0,250mMNaCl,1mMDTT,50%Glycerol |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.Mangelsdorf,D.J.,etal.,(1995)Cell83,835–839 2.Glass,C.K.(1994)Endocrinol.Rev.15,391–407 3.Moras,D.,etal.,(1998)Curr.Opin.CellBiol.10,384-391 4.KliewerS.A.,etal.,(1992)Nature355,446–449 5.GlassC.K.,etal.,(1989)Cell59,697-708 6.NagyL.,etal.,(1997)Cell89,373-380 7.Heinzel,T.,etal.,(1997)Nature387,43-48 8.Onate,S.A.,etal.,(1995)Science270,1354-1357 9.Kamei,Y.,etal.,(1996)Cell85,403-414 10.Blanco,J.C.,etal.,(1998)GenesDev.12,1638-1651 11.Fondell,J.D.,etal.,(1996)Proc.Natl.Acad.Sci.USA93,8329-8333 12.Wolffe,A.,etal.,(1997)GenesCells2,291-302 |
品牌介绍
ExcelGene是一家私人拥有和科学驱动的公司，由Florian M.Wurm教授于2001年创建，自2017年起由首席执行官Maria João Wurm博士领导。我们的总部设在瑞士的蒙蒂。F、 Wurm是旧金山南部基因科技公司（Genentech Inc.）的前经理和科学家，也是为第一批在CHO细胞中制造药物蛋白质而开发制造工艺的先驱科学家之一。Maria J.De Jesus，现在的Maria J.Wurm，ExcellGene的共同创始科学家，在位于洛桑的瑞士联邦理工学院（EPFL）担任高级科学家，发明并开发了多项突破性技术。这些发明对细胞系的发展产生了深远的影响，有些已经在临床生物制剂的早期研发工作中得到了全球应用。ExcelGene面向全球客户，致力于挑战蛋白质表达目标。
