Excellgen/Farnesoid-X活化受体/RP-144/10000 U
市场价：
¥4400.00
美元价：
1980.00
产品分类：
转录表达
公司分类：
Target_Expression
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductName | Farnesoid-X-activatedReceptor,FarnesoidXreceptor |
| Size | 10,000U |
| Description | Farnesoid-X-receptor(FXR)wasoriginallyidentifiedandclonedinratasanorphannuclearhormonereceptorbasedonhybridizationwithadegenerateoligonucleotidedesignedfromthehighlyconservednuclearhormonereceptorDNAbindingdomain(1).FXRfunctionsasaheterodimerwithRXRandbindstosequenceelementsinthepromotersoftargetgenes.TheFXR/RXRheterodimerbindswithhighestaffinitytoinvertedrepeatsseparatedby1bp(IR-1)andwithlowaffinitytodirectrepeatsseparatedby4and5bp(DR-4andDR-5)(1,2).Asisthecaseforothernuclearhormonereceptors,FXRregulatestargetgeneactivityinresponsetoligand.WhileinitialstudiessuggestedthatfarnesolandretinoidmetaboliteswerelikelyligandsforFXR,currentdatasupportthenotionthatFXRisabileacidsensorthatplaysanintegralroleinbileacidsynthesisandtransport(1,3-6).Inthesmallintestine,FXRregulatesbileaciduptakethroughtheupregulationoftheilealbileacidbindingproteingeneviabindingtoanupstreamresponseelement(7).TheFXR/RXRheterodimercanbeactivatedbythebilesaltchenodeoxycholicacid(CDCA)andFXRisrequiredforthebilesalt-dependenttranscriptionalcontrolofthehumanABCB11gene(thebilesaltexportpump)(8).Inaddition,FXRhasbeenshowntoinhibitthecholesterol7-hydrolasegene(CYP7A1)transcription(9). |
| Applications | FXRhasbeenappliedinDNAandprotein-proteininteractionsassays |
| Source | E.coli |
| FusionTag | HisTag |
| PurificationMethod | FPLC |
| UnitDefinition(Activity) | 1unitequalsto1nanogrampurifiedprotein.20unitsaresufficientforagel-mobilityshiftassayand100unitsaresufficientforaprotein-proteininteractionassay |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 9971 |
| GeneName | FXR |
| GeneSynonyms | BAR;FXR;HRR1;HRR-1;RIP14 |
| MW | 56.6kDa |
| ProteinSequence | MGSKMNLIEHSHLPTTDEFSFSENLFGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQ ISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGR IKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQ ECRLRKCKEMGMLAECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCR EKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVE FTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDE YITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCK IHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ |
| StorageBuffer | 20mMTris-HCl,pH8.0,250mMNaCl,50%Glycerol |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.Formanetal.,(1995)Cell81,687-693 |
品牌介绍
ExcelGene是一家私人拥有和科学驱动的公司，由Florian M.Wurm教授于2001年创建，自2017年起由首席执行官Maria João Wurm博士领导。我们的总部设在瑞士的蒙蒂。F、 Wurm是旧金山南部基因科技公司（Genentech Inc.）的前经理和科学家，也是为第一批在CHO细胞中制造药物蛋白质而开发制造工艺的先驱科学家之一。Maria J.De Jesus，现在的Maria J.Wurm，ExcellGene的共同创始科学家，在位于洛桑的瑞士联邦理工学院（EPFL）担任高级科学家，发明并开发了多项突破性技术。这些发明对细胞系的发展产生了深远的影响，有些已经在临床生物制剂的早期研发工作中得到了全球应用。ExcelGene面向全球客户，致力于挑战蛋白质表达目标。
