Excellgen/Liver-X受体α亚型/RP-145/10000 U
市场价:
¥4400.00
美元价:
1980.00
产品分类:
转录表达
公司分类:
Target_Expression
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
ProductName | Liver-XReceptoralphaisoform |
Size | 10,000U |
Description | LiverXreceptors(LXRs)arenuclearreceptorsthatregulatethemetabolismofcholesterolandbileacids(1).TherearetwosubtypesofLXRs,LXRαandLXRβ.LXRβispreferentiallyexpressedinliver,smallintestine,kidneyandspleen(2,3).Incontrast,LXRαexpressionisubiquitous(4).ThegenomicstructureandthepromoterregionsofthetwoLXRgenescontainspecificregulatorysites,whichsuggestthatLXRsmayhavephysiologicalrolesintheimmunesystem(5).Likeothernuclearreceptors,LXRsheterodimerizewithretinoidXreceptor(RXR)forfunction(1).LXRsareactivatedbynaturallyoccurringoxysterolsandregulatetheexpressionoftargetgenes(6-8),includingATPbindingcassettetransporter1(ABC1),ATPbindingcassettetransporter8(ABC8)andcholesterolestertransferprotein(CETP)(9-10).LXRαisthoughttoplayamajorroleinthecontrolofcholesterolcatabolismbystimulatingtheexpressionofcholesterol7alpha-hydroxylase(CYP7A1),theratelimitingenzymeofbileacidsynthesis(11) |
Applications | LXRhasbeenappliedinDNAandprotein-proteininteractionsassays |
Source | E.coli |
FusionTag | 6XHis |
PurificationMethod | FPLC |
UnitDefinition(Activity) | 1unitequalsto1nanogramofpurifiedprotein.20unitsaresufficientforagel-mobilityshiftassayand100unitsaresufficientforaprotein-proteininteractionassay |
Purity | ~95%asdeterminedbySDS-PAGE |
GeneID | 10062 |
Accession# | NM_005693 |
GeneName | NR1H3 |
GeneSynonyms | NR1H3;LXRAandRLD-1 |
MW | 53.7kDa |
ProteinSequence | SLWLGAPVPDIPPDSAVELWKPGAQDASSQAQGGSSCILREEARMPHSAGGTAGVGLEAA EPTALLTRAEPPSEPTEIRPQKRKKGPAPKMLGNELCSVCGDKASGFHYNVLSCEGCKGF FRRSVIKGAHYICHSGGHCPMDTYMRRKCQECRLRKCRQAGMREECVLSEEQIRLKKLKR QEEEQAHATSLPPRRSSPPQILPQLSPEQLGMIEKLVAAQQQCNRRSFSDRLRVTPWPMA PDPHSREARQQRFAHFTELAIVSVQEIVDFAKQLPGFLQLSREDQIALLKTSAIEVMLLE TSRRYNPGSESITFLKDFSYNREDFAKAGLQVEFINPIFEFSRAMNELQLNDAEFALLIA ISIFSADRPNVQDQLQVERLQHTYVEALHAYVSIHHPHDRLMFPRMLMKLVSLRTLSSVH SEQVFALRLQDKKLPPLLSEIWDVHE |
StorageBuffer | 20mMTris-HCl,pH8.0,250mMNaCl,50%Glycerol |
Storage | -20to-80°C. |
Shipping | 4°Cordryice |
References | 1.Peetetal.,(1998)Curr.Opin.Gent.Dev.8,571-575 2.Willyetal.,(1995)GenesDev.9,1033-1045 3.Apfeletal.,(1994)Mol.Cell.Biol.14,7025-7035 4.Songetal.,(1994)Proc.Natl.Acad.Sci.91,10809-10813 5.Albertietal.,(2000)Gene243,93-103 6.Janowskietal.,(1996)Nature383,728-731 7.Lehmannetal.,(1997)J.Biol.Chem.272,3137-3140 8.Janowskietal.,(1999)Proc.Natl.Acad.Sci.96,266-271 9.Luoetal.,(2000)J.Clin.Invest.105,513-520 10.Venkateswaranetal.,(2000)J.Biol.Chem.275,14700-14707 11.Peetetal.,(1998)Cell93,693-704 |
品牌介绍
ExcelGene是一家私人拥有和科学驱动的公司,由Florian M.Wurm教授于2001年创建,自2017年起由首席执行官Maria João Wurm博士领导。我们的总部设在瑞士的蒙蒂。F、 Wurm是旧金山南部基因科技公司(Genentech Inc.)的前经理和科学家,也是为第一批在CHO细胞中制造药物蛋白质而开发制造工艺的先驱科学家之一。Maria J.De Jesus,现在的Maria J.Wurm,ExcellGene的共同创始科学家,在位于洛桑的瑞士联邦理工学院(EPFL)担任高级科学家,发明并开发了多项突破性技术。这些发明对细胞系的发展产生了深远的影响,有些已经在临床生物制剂的早期研发工作中得到了全球应用。ExcelGene面向全球客户,致力于挑战蛋白质表达目标。