当前位置：
首页
>
产品中心 >
Target_Expression >
Excellgen/Brahma-related Gene 1, (K798R, ATPase-deficient), BRG1, SMARCA4/RP-23/5,000 U
Excellgen/Brahma-related Gene 1, (K798R, ATPase-deficient), BRG1, SMARCA4/RP-23/5,000 U
市场价：
¥6800.00
美元价：
3060.00
产品分类：
转录表达
公司分类：
Target_Expression
联系Q Q：
3392242852
电话号码：
4000-520-616
电子邮箱：
info@ebiomall.com
商品介绍
| ProductName | Brahma-relatedGene1,(K798R,ATPase-deficient),BRG1,SMARCA4 |
| Size | 5,000U |
| Description | BRG1isanessentialcomponentoftheSWI/SNFchromatinremodelingcomplexesandisimplicatedinmultiplefunctionsthroughitsinteractionwithdifferentproteins,includingthetumorsuppressorproteinpRb(Cat#P2007)(1),serine-threoninekinaseLKB1(2),andothertranscriptionfactors(3,4).Mutationoflysinetoarginineatposition798intheDNA-dependentATPasedomainofBRG1a)failedtorestorenormalgrowthtoswi2-cells(5),b)reduceditsABIlitytorepressc-fostranscription(6),andc)reducedCIITA(classIItransactivator)inductionandenhancedtherateofinductionoftheinterferon-g-responsiveGBP-1gene(7). |
| Applications |
|
| Source | Baculovirus-insectcell |
| FusionTag | His |
| PurificationMethod | FPLC |
| UnitDefinition(Activity) | 1unitequalsto1nanogrampurifiedprotein.50-100unitsarerequiredforaninvitronucleosomeremodelingassayand100unitsarerequiredforaprotein-proteininteractionassay. |
| Purity | ~95%asdeterminedbySDS-PAGE |
| GeneID | 6597 |
| Accession# | NM_003072 |
| GeneName | SWI/SNFrelated,matrixassociated,actindependentregulatorofchromatin,subfamilya,member4 |
| GeneSymbol | SMARCA4 |
| GeneSynonyms | BRG1;SNF2;SWI2;MRD16;RTPS2;BAF190;SNF2L4;SNF2LB;hSNF2b;BAF190A |
| MW | 189.0kDa |
| ProteinSequence | 1MSTPDPPLGGTPRPGPSPGPGPSPGAMLGPSPGPSPGSAHSMMGPSPGPPSAGHPIPTQG 61PGGYPQDNMHQMHKPMESMHEKGMSDDPRYNQMKGMGMRSGGHAGMGPPPSPMDQHSQGY 121PSPLGGSEHASSPVPASGPSSGPQMSSGPGGAPLDGADPQALGQQNRGPTPFNQNQLHQL 181RAQIMAYKMLARGQPLPDHLQMAVQGKRPMPGMQQQMPTLPPPSVSATGPGPGPGPGPGP 241GPGPAPPNYSRPHGMGGPNMPPPGPSGVPPGMPGQPPGGPPKPWPEGPMANAAAPTSTPQ 301KLIPPQPTGRPSPAPPAVPPAASPVMPPQTQSPGQPAQPAPMVPLHQKQSRITPIQKPRG 361LDPVEILQEREYRLQARIAHRIQELENLPGSLAGDLRTKATIELKALRLLNFQRQLRQEV 421VVCMRRDTALETALNAKAYKRSKRQSLREARITEKLEKQQKIEQERKRRQKHQEYLNSIL 481QHAKDFKEYHRSVTGKIQKLTKAVATYHANTEREQKKENERIEKERMRRLMAEDEEGYRK 541LIDQKKDKRLAYLLQQTDEYVANLTELVRQHKAAQVAKEKKKKKKKKKAENAEGQTPAIG 601PDGEPLDETSQMSDLPVKVIHVESGKILTGTDAPKAGQLEAWLEMNPGYEVAPRSDSEES 661GSEEEEEEEEEEQPQAAQPPTLPVEEKKKIPDPDSDDVSEVDARHIIENAKQDVDDEYGV 721SQALARGLQSYYAVAHAVTERVDKQSALMVNGVLKQYQIKGLEWLVSLYNNNLNGILADE 781MGLGKTIQTIALITYLMEHRRINGPFLIIVPLSTLSNWAYEFDKWAPSVVKVSYKGSPAA 841RRAFVPQLRSGKFNVLLTTYEYIIKDKHILAKIRWKYMIVDEGHRMKNHHCKLTQVLNTH 901YVAPRRLLLTGTPLQNKLPELWALLNFLLPTIFKSCSTFEQWFNAPFAMTGEKVDLNEEE 961TILIIRRLHKVLRPFLLRRLKKEVEAQLPEKVEYVIKCDMSALQRVLYRHMQAKGVLLTD 1021GSEKDKKGKGGTKTLMNTIMQLRKICNHPYMFQHIEESFSEHLGFTGGIVQGLDLYRASG 1081KFELLDRILPKLRATNHKVLLFCQMTSLMTIMEDYFAYRGFKYLRLDGTTKAEDRGMLLK 1141TFNEPGSEYFIFLLSTRAGGLGLNLQSADTVIIFDSDWNPHQDLQAQDRAHRIGQQNEVR 1201VLRLCTVNSVEEKILAAAKYKLNVDQKVIQAGMFDQKSSSHERRAFLQAILEHEEQDESR 1261HCSTGSGSASFAHTAPPPAGVNPDLEEPPLKEEDEVPDDETVNQMIARHEEEFDLFMRMD 1321LDRRREEARNPKRKPRLMEEDELPSWIIKDDAEVERLTCEEEEEKMFGRGSRHRKEVDYS 1381DSLTEKQWLKAIEEGTLEEIEEEVRQKKSSRKRKRDSDAGSSTPTTSTRSRDKDDESKKQ 1441KKRGRPPAEKLSPNPPNLTKKMKKIVDAVIKYKDSSSGRQLSEVFIQLPSRKELPEYYEL 1501IRKPVDFKKIKERIRNHKYRSLNDLEKDVMLLCQNAQTFNLEGSLIYEDSIVLQSVFTSV 1561RQKIEKEDDSEGEESEEEEEGEEEGSESESRSVKVKIKLGRKEKAQDRLKGGRRRPSRGS 1621RAKPVVSDDDSEEEQEEDRSGSGSEED |
| StorageBuffer | 20mMTris-Cl(pH8.0),20%Glycerol,100mMKCl,1mMDTTand0.2mMEDTA |
| Storage | -20to-80°C. |
| Shipping | 4°Cordryice |
| References | 1.Dunaief,J.L.etal.,(1994)Cell79,119-130 2.Marignani,P.A.etal.,(2001)J.Biol.Chem.276,32415-32418 3.Brockmann,D.etal.,(2001)Gene277,111-120 4.Barker,N.etal.,(2001)EMBOJ.20,4935-4943 5.Khavari,P.A.etal.,(1993)Nature366,170-174 6.Murphy,D.J.etal.,(1999)Mol.Cell.Biol.19,2724-2733 7.Pattenden,S.G.etal.,(2002)EMBOJ.21,1978-1986 |
品牌介绍
ExcelGene是一家私人拥有和科学驱动的公司，由Florian M.Wurm教授于2001年创建，自2017年起由首席执行官Maria João Wurm博士领导。我们的总部设在瑞士的蒙蒂。F、 Wurm是旧金山南部基因科技公司（Genentech Inc.）的前经理和科学家，也是为第一批在CHO细胞中制造药物蛋白质而开发制造工艺的先驱科学家之一。Maria J.De Jesus，现在的Maria J.Wurm，ExcellGene的共同创始科学家，在位于洛桑的瑞士联邦理工学院（EPFL）担任高级科学家，发明并开发了多项突破性技术。这些发明对细胞系的发展产生了深远的影响，有些已经在临床生物制剂的早期研发工作中得到了全球应用。ExcelGene面向全球客户，致力于挑战蛋白质表达目标。
